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If you are lean and must use the thigh, always pinch the skin, use a 45-degree angle, and consider a shorter needle (3/8 inch instead of 1/2 inch) to reduce intramuscular injection risk

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Xenobiotica 45(10):903911 Loureiro AI, Bonifcio MJ, Fernandes-Lopes C, Pires N, Igreja B, Wright LC, Soares-da-Silva P (2015) Role of P-glycoprotein and permeability upon the brain distribution and pharmacodynamics of etamicastat: a comparison with nepicastat